The species have large genomes up to 9 mbp, distributed into 25 replicons. It has been reported that culture filtrates of clinically derived strains of b. The other group consists of nonpathogenic species with skills to promote plant growth and rhizoremediation. Isolation and identification of burkholderia species in soils and various water reservoirs aw yee shan the genus burkholderia consists of diverse species which include both friends and foes. Burkholderia cepacia mkta 25416, excellent and quickly, with white, yellow or salmonpink colonies, it turns to pinkfuchsia the medium. Burkholderia tropica una bacteria con gran potencial. Burkholderia cepacia pseudomonas cepacia bacteriology a bacterium found in the environmenteg, plants, water, soil, and in hospital environment, which may colonize the respiratory tract of pts with cystic fibrosis. Some of these species pose serious risks to the health of a person with cystic fibrosis.
While the infection is most often symptomfree, it can turn serious, and even lifethreatening. The outcome may also be affected by the particular strain of. Burkholderia cepacia in pharmaceutical industries 33 copright. Cdc is collaborating with the food and drug administration fda, state and local health departments, and healthcare facilities to investigate recent outbreak of burkholderia cepacia infections associated with exposure to liquid docusate. Update 10272017 fda testing has identified burkholderia cepacia in several bottles of rugby diocto docusate sodium oral liquid from lot no.
Burkholderia cepacia has long been known as both a plant and human pathogen. Burkholderia cepacia in people with cystic fibrosis. Burkholderia cepacia a bacterial species found in rotted onions and in clinical specimens. In the past 2 decades, burkholderia cepacia has emerged as a human pathogen causing numerous outbreaks, particularly among cystic fibrosis cf patients. Burkholderia pseudomallei, causative agent of melioidosis. Agricultural use of burkholderia pseudomonas cepacia. Learn about the characteristics of these bacteria and how to identify them. Burkholderia cepacia, a bacteria which used to be called pseudomonas cepacia, is a rare but significant threat to people living with cystic fibrosis cf. Eradication therapy for burkholderia cepacia complex in people with cystic fibrosis. Tem baixa virulencia, raramente causa problemas a individuos saudaveis.
When using the usual commercial test procedures or selective media burkholderia cepacia were often identified or overlooked wrong. They have been found to possess multitrichous polar flagella as well as pili used for attachment. Burkholderia cepaciais being recognized more often as etiologic agent of nosocomial bacteremia nb in children. This chapter discusses the general characteristics of the bcc group. Burkholderia cepacia diagnosis and prevalence of resistance. With regard to pca standard, counting 294% pseudomonas aeruginosa mkta 9027, poor, slow and without turning the medium pseudomonas fluorescens mkta 525, inhibited or slow and without turning the medium. Burkholderia cepacia complex bcc, or simply burkholderia cepacia, is a group of catalaseproducing, lactosenonfermenting, gramnegative bacteria composed of at. Pseudomonas cepacia definition of pseudomonas cepacia by. En estados unidos, estos germenes con mayor frecuencia ocasionan problemas en circunstancias como las siguientes.
Bcc causes infections that include bacteraemia, urinary tract infection, septic. Burkholderia cepacia complex bcc is an important nosocomial pathogen in hospitalised patients, particularly those with prior broadspectrum antibacterial therapy. Burkholderia cepacia kyon veterinary surgical products. Burkholderia previously known as pseudomonas cepacia, a nutritionally versatile, gramnegative organism, was first described in 1949 by walter burkholder of cornell university, as the phytopathogen responsible for a bacterial rot of onions. Pdf taxonomy and identification of the burkholderia. Fda updates on 2017 burkholderia cepacia contamination. Burkholderia cepacia refers to a group of bacteria that can cause infections in the body, most often infecting the lungs. A medicine called meropenem is the most active drug used to treat b cepacia. Some strains of burkholderia bacteria are spread from person to person or by contamination of disinfectants, including in hospital settings. Burkholderia cepacia is an opportunistic pathogen that has become a major threat to individuals with cystic fibrosis cf. Sep 15, 2003 persons with cystic fibrosis cf are susceptible to chronic respiratory tract infection with a variety of bacteria. Oct 27, 2017 update 10272017 fda testing has identified burkholderia cepacia in several bottles of rugby diocto docusate sodium oral liquid from lot no. Cdc is collaborating with the food and drug administration fda, state and local health departments, and healthcare facilities to investigate recent outbreak of burkholderia cepacia infections associated with exposure to liquid docusate fda has released a statement regarding a voluntary recall external icon of multiple brands of. Germs burkholderia cepacia faqs print email burkholderia cepacia faqs what is the burkholderta cepacta complex.
Transmissibility and infection control implications of. There are about 17 species that make up the complex but the most common are. Characteristics of patients with burkholderia cepacia. Lanes ad, burkholderia cenocepacia recovered march 1998, april 1999, september 2000, and april 2001, respectively. Burkholderia cepacia wikipedia, a enciclopedia livre. Our objective is to describe the clinical and laboratory features, and possible risk factors for the development of hospitalacquired b. Positive culture for burkholderia cepacea in the surgical site end of surgery repeatedly positive for several months negative culture for bcc from the surgical environment walls. Given its potential ubiquity, it is not surprising to see that the bacterium is associated. They are gramnegative saprophytes living in the soil and water. National committee for clinical laboratory standards institute nccls.
Burkholderia cepacia agent information sheet research. It is also found in nosocomial infections and is difficult to eradicate due to intrinsic resistance to several antibiotics. These include species within the burkholderia cepacia complex, a group of 9 closely related species or genomovars that until recently were all identified as b. In vitro efficacy of high dose tobramycin against burkholderia cepacia complex and stenotrophomonas maltophilia isolates from cystic fibrosis patients. Jun 27, 2016 the cdc and fda have joined forces with various state and local health departments and health care facilities to investigate a multistate outbreak of burkholderia cepacia infections. This antibacterial is typically given intravenously in the hospital and often prescribed in combination with other drugs. The genus burkholderia whit over 90 species reported to date, is divided into two major groups phylogenetically distant. Given its potential ubiquity, it is not surprising to. The burkholderia cepacia complex is a group of 22 species, which are known as opportunistic pathogens in immunocompromised people, especially those suffering from cystic fibrosis. Multistate outbreak of burkholderia cepacia infections. Quality assurance for commercially prepared microbiological culture media, m22a3, vol 24, n. Burkholderia cepacia burkholdereeuh sipaysheeuh also called b. Burkholderia cepacia, epidemiology, polymerase chain reaction burkholderia pseudomonas cepacia is an uncommon human pathogen and is also recognized as an environ mental bacterium l. The first group is made up of pathogenic species which highlights referred opportunistic pathogens such as burkholderia cepacia bcc complex.
Click the button below to download a pdf of our latest catalog. Cdc warns of multistate outbreak of burkholderia cepacia. Burkholderia is a genus of proteobacteria whose pathogenic members include the burkholderia cepacia complex which attacks humans and burkholderia mallei, responsible for glanders, a disease that occurs mostly in horses and related animals. Bcc causes infections that include bacteraemia, urinary tract infection, septic arthritis, peritonitis and respiratory tract infection. Burkholderia cepacia is the name of a specific bacterium in the genus burkholderia it is most common to refer to a group of related bacteria in this genus as burkholderia complex instead of referring to individual species outside of diagnostic, research or infection control environments. Burkholderia cepacia in healthcare settings hai cdc. Burkholderia cepacia are aerobic rodshaped, freeliving, motile gram negative bacteria ranging from 1. July 1999 summary t his is a summary of the cystic fibrosis trust infection control groups recommendations on.
Burkholderia cepacia definition of burkholderia cepacia by. Summary the increasing challenge posed by multiresistant saprophytes in medical microbiology is strikingly demonstrated by the emergence of burkholderia formerly pseudomonas cepacia as an opportunist pathogen in immunocompromised patients, particularly individuals with chronic granulomatous disease and cystic fibrosis cf. The detection of the pathogen is done by growing from respirationstraktmaterialien. Burkholderia cepacia has the ability to use these compounds as a source of carbon and energy, therefore breaking them down and removing them from the environment 4. Burkholderia cepacia complex choose one burkholderia cepacia atcc 25416 burkholderia cepacia bu72 burkholderia cepacia csv90 burkholderia cepacia gg4 burkholderia cepacia jbk9 all lower taxonomy nodes 5.
Burkholderia cepacia definition of burkholderia cepacia. It was first discovered as a plant pathogen in 1949 when it was found to cause onion rot. The usp monograph requires no microbial testing for this product. One highly transmissible strain has spread across north america and britain, and another between hospitalized cf and noncf patients. Burkholderia cepacia complex infectious disease and. Es bien reconocida como patogeno nosocomial, produce infeccio. Best known previously as a phytopathogen and the cause of soft rot. In approximately 20% of patients, pulmonary colonization with b. Burkholderia cepacia complex bcc is an important group of pathogens affecting patients with cystic fibrosis and chronic granulomatous disease as well as immunocompromised and hospitalised patients. Burkholderia cepacia can be found in soil, water, and infected plants, animals, and humans. How can a person with cf reduce the chance ot getting b. The agency classified this as a class i recall because the product was contaminated with burkholderia cepacia. View burkholderia cepacia research papers on academia.
1577 542 1062 595 718 539 614 1467 14 1250 1388 1396 188 1122 1314 1204 715 780 405 1469 1329 355 1262 528 90 160 1237 153 1357 1237 1398